ACTION-01 (Phase 1b/III)

Investigator physician : Dr Caroline BOURSIER

Phase 1b/3 randomized, controlled, open-label trial comparing RYZ101 with standard treatment in patients with inoperable, advanced, well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NET) expressing somatostatin receptors (SSTR+) that progressed after prior treatment with a 177Lu-labeled somatostatin analogue (177Lu-SSA)

Gastroenteropancreatic neuroendocrine tumors (GEP-NET)


This study aims to determine the safety, preliminary antitumor activity, and pharmacokinetics (PK) of RYZ101 in combination with standard of care (SoC) therapy consisting of carboplatin + etoposide + atezolizumab in untreated subjects with somatostatin receptor expressing (SSTR+) ES-SCLC.


Treatment: RYZ101 (225Ac-DOTATATE)
Study status : Recruiting
Clinical Trial number : NCT05595460
Funding :

RayzeBio