Created in 2013, the radiochemistry laboratory develops, optimises and produces radiotracers for diagnostic and therapeutic applications.
Part of Nancyclotep, it works hand in hand with the preclinical research team, so that evaluation can be carried on within the platform itself.
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Every project starts with a radiolabelling strategy tailored to the compound and its intended application. The team then develops the production process and the quality control methods, through to a radiotracer ready for preclinical evaluation.
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The laboratory adapts and improves processes to strengthen their yield, reproducibility and stability. It works in particular on molar activity, pH and formulation, and can automate procedures that were initially manual. Design-of-experiments studies also help identify the critical parameters of a process.
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The team produces radiotracers from its own portfolio or according to a process supplied by a partner. Once quality control is completed, they can be handed straight over to the Nancyclotep preclinical team for evaluation.
The laboratory works on a wide variety of compounds, from small molecules to peptides, antibodies, antibody fragments and cells. Depending on the nature of the project, several strategies can be implemented:
A selection of radiotracers can be mobilised for research projects and preclinical studies.
Radiolabelling can be carried out manually or on automated synthesisers, in areas suited to the different activity levels.
The laboratory has the equipment required to check the identity, activity and purity of the radiotracers:
Development, optimisation or production of a radiotracer: tell us about your project and let’s define the most suitable strategy together.
